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首頁(yè) /藥靶模型 /激酶靶點(diǎn) /c-Kit /c-Kit W557G/BaF3

c-Kit W557G/BaF3

CBP73293

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I. Background
KIT W557G lies within the juxtamembrane domain (exon 11) of the Kit protein (PMID: 16226710). W557G results in constitutive phosphorylation of Kit in cell culture (PMID: 23567324), and therefore, is predicted to lead to a gain of Kit protein function.
 
II. Introduction

Cell Line Name:

c-Kit W557G/BaF3

Host Cell:

BA/F3

Stability: 16 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.)

Application:

Anti-proliferation assay and PD assay

Freeze Medium:

90% FBS+10% DMSO

Complete Culture Medium:

RPMI-1640+10%FBS

Mycoplasma Status:

Negative

 
III. Representative Data

1. WB of c-Kit W557G/BaF3

2. Sanger of c-Kit W557G/BaF3

3. Anti-proliferation assay

Figure 3. CTG Proliferation Assay of BaF3 c-KIT W557G Cells (C4).

 

 

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