TIE2/HEK293
CBP74161
                       
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                | I. Background | |
| TIE2(酪氨酸激酶受體)主要表達(dá)于血管內(nèi)皮細(xì)胞表面的受體,胞外區(qū)含免疫球蛋白 域 ( 結(jié) 合 ANG ) 、 EGF 樣 域 ( 介 導(dǎo) 二 聚 化 ) ; 胞內(nèi)區(qū)含酪氨酸激酶活性位點(diǎn) (Y1100/Y1108)。被配體激活后通過 PI3K/AKT 和 MAPK 通路調(diào)控內(nèi)皮細(xì)胞存活、遷移 及血管屏障功能。在病理狀態(tài)下(如膿毒癥、腫瘤),TIE2 信號(hào)異常導(dǎo)致血管滲漏或異常 增生。 | |
| II. Description | |
| TIE2 HEK293 細(xì)胞,在 HEK293 細(xì)胞的基礎(chǔ)上,穩(wěn)定表達(dá)人 TIE2。 | |
| III. Introduction | |
| Host Cell: | HEK293 | 
| Expressed gene: | TIE2 | 
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | 
| Synonym(s): | TIE2,Tie-2,TEK,VMCM, VMCM1,CD202b,Angiopoietin-1 receptor ... | 
| Freeze Medium: | 90% FBS+10% DMSO | 
| Culture Medium: | DMEM+10% FBS+2 μg/ml Puromycin | 
| Storage: | Liquid nitrogen | 
| Application(s): | Binding Assay,FACS | 
| IV. Description of Host Cell Line | |
| Organism: | Homo sapiens, human | 
| Tissue: | Embryonic kidney | 
| Disease: | Normal | 
| Morphology: | Epitheloid cell | 
| Growth Properties: | Adherent | 
| Ⅴ. Representative Data | |
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				 Figure 1. Recombinant HEK293 cell constitutively expressing TIE2.  | 
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